Hyperlipidemia, hyperlipoproteinemia, or hyperlipidaemia (British English) is abnormally elevated levels of any or all lipids and/or lipoproteins in the blood. It is the most common form of dyslipidemia which includes the abnormal production of lipids, fats and cholesterol.
Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of hyperlipidemias. About 1 million people in the US, are having a problem of hyperlipidemia. They either treat this problem by taking anti-hyperlipidemics or by having surgeries like liposuction etc. Hypolipidemics either work by decreasing the triglycerides synthesis in the liver or by reducing the cholesterol level by Inhibiting the production of HMG-CoA reductase, which is a enzyme used by the liver to produce cholesterol. Some of them, combine with bile acids and form insoluble complex which prevents the resorption of bile acids from small intestine. They are also called lipid-lowering drugs.
HOW DO HYPERLIPIDEMICS WORK?
Antihyperlipidemic or hypermipidemics agents promote reduction of lipid levels in the blood. Some antihyperlipidemic agents aim to lower the levels of low-density lipoprotein (LDL) cholesterol, some reduce triglyceride levels, and some help raise the high-density lipoprotein (HDL) cholesterol. By reducing the LDL cholesterol, they can prevent both the primary and secondary symptoms of coronary heart disease.
WHAT DO HYPERLIPIDEMICS DO?
TYPES OF HYPERLIPIDEMICS:
There are various types of hyperlipidemics, that work differently to reduce the fat and lipids. These include:
They reduce the synthesis of triglycerides in the liver. They work by decreasing the VLDL and LDL and they increase the level of HDL.
HMG-CoA reductase inhibitors (HMGs or statins)
They reduce the cholestrol level by Inhibiting the production of HMG-CoA reductase, which is a enzyme used by the liver to produce cholesterol. They lowers the rate of cholesterol production
They are required in higher doses than when used as a vitamin. They work by decreasing the triglycerides. They increases the level of HDL. They are very effective and inexpensive. They are often used in combination with other lipid-lowering agents.
They are necessary for absorption of cholesterol. They work Combining with bile acids and form insoluble complex. They prevent resorption of bile acids from small intestine.
SIDE EFFECTS OF HYPERLIPIDEMICS:
There are some side effects associated with hyperlipidemics which include: